Audience: Educated Lay Audience
Client: Dr. Pawel Kalinski
Date: January, 2019
Art Director: Yana Hammond
Illustrator, Animator & Narrator: Iman Carr
Environment & 3D: Hannah Bryce Ely
In collaboration with ATLAS Studios, Yana Hammond, Hannah Bryce Ely, and I co-wrote, storyboarded, and designed all the visual assets. As the lead animator, I created the animatic and animation. As the art director, Yana Hammond's artwork and style served as inspiration for the scientific illustrations. Hannah Bryce Ely, developed the 3D assets and the environment art.
Roswell Park Comprehensive Cancer Center has developed a novel immunotherapy currently open to patients through clinical trials. This animated video is used to inform patients and help them make educated decisions about participating in relevant clinical trials. It illustrates a development of a new immunotherapy at Roswell Park Comprehensive Cancer Center. The presence of cancer fighting T-cells in tumor microenvironments is critical for the effectiveness of immune therapies and patient outcomes, while regulatory T-cells promote cancer progression. An enzyme, Cyclooxygenase type 2 (COX-2) is blocked to enhance cancer fighting T-cells and inhibit cancer progression or regulatory T-cells attracted to the tumor.
M. N. Theodoraki, S. Y. Sarkar, B Orr, R Muthuswamy, J Voyten, F Modugno, W Jiang, M Grimm, P H Basse, D L Bartlett, R P Edwards, P Kalinski (2018). "Helicase-Driven Activation of NFκB-COX2 Pathway Mediates the Immunosuppressive Component of dsRNA-Driven Inflammation in the Human Tumor Microenvironment." Cancer Res 78(15): 4292-4302.
Retrieved at https://www.ncbi.nlm.nih.gov/pubmed/29853604
Final Animation
Storyboard
Styleframes
Character Animations
